UCB Interim Report for the first three months of 2015:

Strong growth, at constant and actual exchange rates, driven by core medicines - and good progress in R&D

• Revenue up 19%* to € 895 million, +11% at constant currencies. 
• Cimzia^®, Vimpat^® and Neupro^® combined net sales of € 433 million, +36% or +20% at constant currencies. Keppra^® net sales of € 190 million (+14%; +4%)
• R&D update: Phase 3 for Vimpat^® in PGTCS has started 
• Financial outlook 2015 confirmed

Brussels (Belgium), 30 April 2015 – 7:00 (CET) – regulated information – 
"UCB had a good start into the year serving more and more patients living with neurological or immunological diseases. At the same time, Cimzia^®, Vimpat^® and Neupro^®, show strong growth at both, constant and actual exchange rates. We are also making good progress with our early and late-stage clinical development activities," said Jean-Christophe Tellier, CEO UCB. 

Revenue reported for the first three months of 2015 are € 895 million, a plus of 19%* or 11% at constant exchange rates (CER) driven by the strong growth of Cimzia^®, Vimpat^® and Neupro^® with combined net sales of € 433 million, while Keppra^® reached € 190 million – the four medicines together represent 70% of UCB's revenue in the first quarter 2015. 

For Cimzia^® (certolizumab pegol) for inflammatory TNF mediated diseases, UCB reports net sales of € 227 million, +42% (+24% CER), supported by continuously broadened access to patients with active psoriatic arthritis or severe active axial spondyloarthritis. Cimzia^® net sales in Japan are reflecting the order pattern of our partner while the in-market growth was positive (+36%).

Vimpat^® (lacosamide) for epilepsy reached net sales of € 146 million, an increase of 39% (+20% CER). In the U.S. and since September 2014, Vimpat^® is also available for monotherapy treatment of partial onset seizures.

For Neupro^® (rotigotine), the patch for Parkinson’s disease and restless legs syndrome, net sales were € 60 million, +14% (+8% CER). 

Keppra^® (levetiracetam) for epilepsy net sales reached € 190 million, up by 14% (+4% CER). In the US, Keppra^® net sales benefited from stocking effects which are not expected to reoccur in the next quarters.

Financial outlook 2015 confirmed:
UCB expects the continued growth of Cimzia^®, Vimpat^®, Neupro^® to drive overall company growth. 2015 revenue should reach approximately € 3.55-3.65 billion; recurring EBITDA should increase to approximately € 710-740 million. Core earnings per share (EPS) are expected in the range of € 1.90-2.05 based on an average of 193.7 million shares outstanding.

R&D update
The Phase 3 program for Vimpat® in primary generalized tonic-clonic seizures (PGTCS) has started in April 2015. First headline results are expected in 2019. 

In March 2015 E Keppra^® was filed with the Japanese regulatory authorities as adjunctive therapy for PGTCS. In February, the Japanese regulatory authorities approved E Keppra^® as monotherapy in the treatment of partial-onset seizures in people living with epilepsy aged four years and above. 

In February 2015, UCB announced positive Phase 3 top-line results with Neupro^® in the treatment of patients in China with Parkinson’s disease. Regulatory submission is planned in 2015.

In January 2015, brivaracetam as adjunctive therapy for the treatment of partial-onset seizures in patients from 16 years of age with epilepsy was filed with the U.S. and EU regulatory authorities.

In January 2015, Neuropore and UCB entered into world-wide collaboration in the development of a small molecule disease modifying treatment option for people living with Parkinson’s disease. A Phase 1 study is scheduled to start in 2015.

Also in January 2015, for Cimzia^® (certolizumab pegol), Dermira and UCB announced the start of the Phase 3 program in psoriasis. Top-line data from this program are expected in 2017.

All other clinical development programs are continuing as planned.

¹ Emerging markets - BRICMT: Brazil, Russia, India, China, Mexico, Turkey 
^* 2014 revenue have been restated reflecting the treatment of Kremers Urban as discontinued operation.
  All figures are unaudited 

For Further Informaton 

Investor Relations
Antje Witte          
Investor Relations, UCB
T +32.2.559.94.14 antje.witte@ucb.com

Isabelle Ghellynck,
 Investor Relations, UCB
T+32.2.559.9588, isabelle.ghellynck@ucb.com

Corporate Communications
France Nivelle  
Global Communications, UCB
T +32.2.559.9178 france.nivelle@ucb.com

Laurent Schots 
Media Relations, UCB  T+32.2.559.92.64 
Laurent.schots@ucb.com 

About UCB
UCB, Brussels, Belgium (www.ucb.com) is a global biopharmaceutical company focused on the discovery and development of innovative medicines and solutions to transform the lives of people living with severe diseases of the immune system or of the central nervous system. With more than 8500 people in approximately 40 countries, the company generated revenue of € 3.3 billion in 2014. UCB is listed on Euronext Brussels (symbol: UCB). Follow us on Twitter: @UCB_news

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