Since 2015, UCB has embarked on a very important change journey:
the Patient Value Strategy
Disclaimer
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Our Strategic Growth Path Towards 2025
Our Key Medicines
We bring solutions to people living with neurological or immunological diseases.
More about BIMZELX® (bimekizumab)
Reaching more than 18 000 patients globally (Dec 2023)
Indications:
Psoriasis (PSO); Psoriatic Arthritis (PsA); Ankylosing spondylitis (AS); non-radiographic Axial Spondyloarthritis (nr-axSpA)
Loss of Exclusivity (indicative):
2032 in U.S., without patent term extension; 2036 in Europe, 2037 in Japan
Sales:
€ 148 million in 2023
Peak sales guidance:
> € 4 billion
More about BRIVIACT® (brivaracetam)
Reaching more than 190 000 patients globally (MAT Q3/2023)
Indication:
Epilepsy partial-onset seizure, also known as focal seizure
Loss of Exclusivity (indicative):
2026 in Europe & U.S.
Sales:
€ 576 million in 2023
Peak sales guidance:
≥ € 600 million by 2026
BRIVIACT® - prescribing information
More about CIMZIA® (certolizumab pegol)
Reaching more than 180 000 patients globally (MAT Q3/2023)
Indications:
Ankylosing spondylitis (AS); non-radiographic Axial Spondyloarthritis (nr-axSpA); Crohn's disease (CD); Psoriasis (PSO); Psoriatic arthritis (PsA); Rheumatoid arthritis (RA)
Loss of Exclusivity (indicative):
2024 in Europe & U.S.
2026 in Japan
Sales:
€ 2 087 million in 2023
Peak sales guidance:
≥ € 2 billion by 2024
achieved in 2022
AS - prescribing information
nr-axSpA - prescribing information
CD - prescribing information
PSO - prescribing information
PsA - prescribing information
RA - prescribing information
More about EVENITY® (romosozumab)
Reached more than 600 000 patients globally since launch (Dec 2023)
Indication:
Osteoporosis
Loss of Exclusivity (indicative):
2031 in Europe and Japan
2033 in U.S.
Sales:
€ 60 million in 2023 in Europe
Net sales outside Europe reported by Amgen and Astellas
More about FINTEPLA® (fenfluramine)
Reaching more than 3 000 patients globally (Dec 2023)
Indications:
Dravet Syndrome, Lennox-Gastaut Syndrome
Loss of Exclusivity (indicative)
2032 in Europe and Japan, 2033 in U.S.
Sales:
€ 226 million in 2023
Peak sales guidance:
€ 800 million by 2027
More about KEPPRA® (levetiracetam)
Reaching more than 1.7 million patients globally (MAT Q3/2023)
Indications:
Epilepsy partial-onset seizures, also known as focal seizures; Epilepsy primary generalized tonic-clonic seizures; Epilepsy myoclonic seizures
Loss of Exclusivity:
U.S. - 2008
Europe - 2010
Japan - 2020
Sales:
€ 636 million in 2023
Peak sales:
€ 1.2 billion (2008)
More about NAYZILAM® (midazolam nasal spray)
Reaching more than 70 000 patients in the U.S. (MAT Q3/2023)
Indication:
Epilepsy seizure clusters
Loss of Exclusivity (indicative):
2028 in U.S.
Sales:
€ 94 million in 2023
More about RYSTIGGO® (rozanolixizumab)
Launched in the U.S. in July 2023, approved in Europe and Japan
Indication:
generalized Myasthenia Gravis
Loss of Exclusivity (indicative):
2033 in Japan. 2034 in Europe and 2035 in U.S., all without patent term extension
Sales:
€ 19 million in 2023
More about VIMPAT® (lacosamide)
Reaching more than 500 000 patients globally (MAT Q3/2023)
Indications:
Epilepsy partial-onset seizures, also known as focal seizures; Epilepsy primary generalized tonic-clonic seizures
Loss of Exclusivity:
2022 in Europe & U.S.
2024 in Japan (indicative)
Sales:
€ 394 million in 2023
Peak sales:
€ 1.5 billion (2021)
VIMPAT® - prescribing information
More about ZILBRYSQ® (zilucoplan)
Global launches starting Q1/2024
Indication:
generalized Myasthenia Gravis
Loss of Exclusivity (indicative):
2035 in Europe, Japan & U.S. without patent term extension
Our Partnerships
Our Pipeline
In a challenging environment, our pipeline builds the basis of UCB’s sustainable long-term growth.
We continued to create value for patients, advancing our pipeline of potential solutions for severe diseases, expanding our capabilities by investing in state-of-the-art scientific platforms and medical advances, and further progress on our digital business transformation journey.
General information
All medicines must pass safety and efficacy tests if they are to be approved by regulators. This is done through a series of rigorous clinical studies, also referred to as clinical trials, research studies or medical research.
More information is available here.
Clinical studies index
UCB is committed to sharing information on studies and making study results publicly accessible. You will find below links to the clinical studies (Phase 2-4) of our main R&D projects.
More information about our clinical studies index and our position paper are available here.
Rozanolixizumab is an investigational humanized monoclonal antibody that specifically binds to human neonatal Fc receptor (FcRn). It has been designed to block the interaction of FcRn and IgG, inhibiting IgG recycling and inducing the removal of pathogenic IgG autoantibodies.
Rozanolixizumab is an investigational humanized monoclonal antibody that specifically binds to human neonatal Fc receptor (FcRn). It has been designed to block the interaction of FcRn and IgG, inhibiting IgG recycling and inducing the removal of pathogenic IgG autoantibodies.
Rozanolixizumab is an investigational humanized monoclonal antibody that specifically binds to human neonatal Fc receptor (FcRn). It has been designed to block the interaction of FcRn and IgG, inhibiting IgG recycling and inducing the removal of pathogenic IgG autoantibodies.
Rozanolixizumab is an investigational humanized monoclonal antibody that specifically binds to human neonatal Fc receptor (FcRn). It has been designed to block the interaction of FcRn and IgG, inhibiting IgG recycling and inducing the removal of pathogenic IgG autoantibodies.
Fenfluramine is an investigational serotonin releasing agent, that has shown to stimulate multiple 5-HT receptor sub-types through the release of serotonin. Fenfluramine may reduce seizures by acting as an agonist at specific serotonin receptors in the brain, including the 5-HT1D, 5-HT2A, and 5-HT2C receptors, and also by acting on the sigma-1 receptor
Fenfluramine is an investigational serotonin releasing agent, that has shown to stimulate multiple 5-HT receptor sub-types through the release of serotonin. Fenfluramine may reduce seizures by acting as an agonist at specific serotonin receptors in the brain, including the 5-HT1D, 5-HT2A, and 5-HT2C receptors, and also by acting on the sigma-1 receptor
MT1621 is an investigational therapy that combines two small molecules, deoxycytidine (dC) and deoxythymidine (dT). It targets the underlying pathophysiology of Thymidine kinase 2 deficiency (TK2d) by restoring mitochondrial DNA (mtDNA) replication fidelity.
MT1621 is an investigational therapy that combines two small molecules, deoxycytidine (dC) and deoxythymidine (dT). It targets the underlying pathophysiology of Thymidine kinase 2 deficiency (TK2d) by restoring mitochondrial DNA (mtDNA) replication fidelity.
Dapirolizumab pegol is an investigational humanised monovalent pegylated Fab antibody fragment against the CD40 ligand (CD40L). Through interactions with its receptor, CD40, CD40L plays an important role in regulating interactions between T cells and other immune cells and thus affects several important functional events thought to be involved in autoimmune disease.
Dapirolizumab pegol is being co-developed with Biogen. 1st phase 3 study.
Dapirolizumab pegol is an investigational humanised monovalent pegylated Fab antibody fragment against the CD40 ligand (CD40L). Through interactions with its receptor, CD40, CD40L plays an important role in regulating interactions between T cells and other immune cells and thus affects several important functional events thought to be involved in autoimmune disease.
Dapirolizumab pegol is being co-developed with Biogen. 1st phase 3 study.
STACCATO® alprazolam is an investigational drug-device combination using STACCATO® delivery technology with alprazolam, a benzodiazepine, that has the potential to be the first rescue treatment to be administered by a patient or caregiver in an out-patient setting to rapidly terminate (within 90 seconds) an ongoing seizure.
STACCATO® alprazolam is an investigational drug-device combination using STACCATO® delivery technology with alprazolam, a benzodiazepine, that has the potential to be the first rescue treatment to be administered by a patient or caregiver in an out-patient setting to rapidly terminate (within 90 seconds) an ongoing seizure.
Bepranemab is an investigational recombinant, humanised, full length IgG4 monoclonal anti-tau antibody with specificity for human tau protein.
Bepranemab is being co-developed with Roche/Genentech
Bepranemab is an investigational recombinant, humanised, full length IgG4 monoclonal anti-tau antibody with specificity for human tau protein.
Bepranemab is being co-developed with Roche/Genentech
minzasolmin is an investigational small molecule that prevents the pathological misfolding and accumulation of alpha-synuclein, a protein which plays a role in Parkinson’s disease (PD) pathology. Inhibition of alpha-synuclein misfolding has the potential to slow down the progression of PD.
minzasolmin belongs to a series of molecules discovered by Neuropore, which were in-licensed by UCB in 2014.
minzasolmin is being co-developed with Novartis.
minzasolmin is an investigational small molecule that prevents the pathological misfolding and accumulation of alpha-synuclein, a protein which plays a role in Parkinson’s disease (PD) pathology. Inhibition of alpha-synuclein misfolding has the potential to slow down the progression of PD.
minzasolmin belongs to a series of molecules discovered by Neuropore, which were in-licensed by UCB in 2014.
minzasolmin is being co-developed with Novartis.
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