UCB presents key data from Alzheimer’s and Parkinson’s disease research programs at AD/PD 2025

Brussels, Belgium – 1 April 2025 – 7AM CET – UCB, a global biopharmaceutical company, today announced it will present 8 scientific abstracts, including 3 late-breaker oral presentations, highlighting key data from its innovative neurodegeneration research programs in Parkinson’s and Alzheimer’s disease, at this year’s AD/PD 2025 meeting, Vienna, Austria, April 1-4, 2025.

"We are excited to present data on many aspects of our science and patient-driven neurodegeneration research program at AD/PD, highlighting promising insights into the underlying mechanisms of Alzheimer’s and Parkinson’s disease. The findings represent an important step forward in our efforts to develop effective treatments, bringing us closer to addressing these devastating neurodegenerative conditions,” said Alistair Henry, Chief Scientific Officer, UCB.

In Alzheimer’s disease, topline results from the TOGETHER phase 2a trial of bepranemab were released in October 2024 - the first study to provide evidence for clinical efficacy of anti-tau therapy in Alzheimer’s disease2 – and a subgroup analysis of this data is presented at AD/PD.¹

In Parkinson’s disease, UCB’s research program includes investigating mechanisms to inhibit the misfolding and propagation of alpha-synuclein - processes believed to underlie the spread of neurodegeneration. Alongside this, the company is advancing research into new therapies for symptom control, recognizing the diverse needs of each patient throughout their disease trajectory. Assets include UCB7853, currently under investigation for preventing extracellular alpha-synuclein spread, and glovadalen (UCB0022), an orally available, brain-penetrant, small molecule, designed to enhance the potency of dopamine ‘when and where needed’ to activate the dopamine D1 receptor and thereby improve symptom control.^6,7

Data at AD/PD include results from ORCHESTRA, a phase II proof-of-concept study assessing the efficacy and safety of minzasolmin in people with early-stage Parkinson’s disease.⁸ UCB previously announced this study did not meet its primary or secondary clinical endpoints.⁹

Data presentations at AD/PD

Alzheimer’s disease

• Barton M, et al. Phase II study of bepranemab in people with prodromal-mild Alzheimer’s disease: Population subgroup analysis. (Late-breaker oral presentation)
• Byrnes W, et al. Safety MRI and volumetric MRI results from TOGETHER, a double-blind, placebo-controlled phase II study of bepranemab in prodromal-mild Alzheimer’s disease. (Late-breaker oral presentation)

Parkinson’s disease

• Carson S, et al. Results from ORCHESTRA, a phase II proof-of-concept study assessing the efficacy and safety of minzasolmin in people with early-stage Parkinson’s disease. (Late-breaker oral presentation)
• Downey P, et al. A preclinical evaluation of UCB7853, an anti-alpha-synuclein antibody in clinical development for Parkinson’s disease. (Poster presentation)
• Kremer P, et al. Phase I study results: UCB7853 safety, tolerability and pharmacokinetics in healthy participants (single-ascending dose) and people with Parkinson’s disease (multiple-ascending doses). (Poster presentation)
• Biagioni M, et al. Designing a patient-informed trial: ATLANTIS Phase II study of the D1 receptor PAM, UCB0022, in advanced Parkinson’s disease. (Poster presentation)
• Morel T, et al. First qualitative assessment of the clinical meaningfulness of MDS-UPDRS Part III in early-stage Parkinson’s disease. (Poster presentation)
• Williamson N, et al. Qualitative patient experience of advanced Parkinson’s disease: A conceptual model of symptoms and health-related quality of life impacts. (Poster presentation)

The safety and efficacy of bepranemab, minzasolmin, glovadalen, and UCB7853 have not been established, and they are not currently approved for use in this indication by any regulatory authority worldwide.

For further information, contact UCB: 

Global Communications
Nick Francis
T: +44 7769 307745
nick.francis@ucb.com

Global Corporate Communications
Laurent Schots
T: +32.2.559.92.64
laurent.schots@ucb.com

Investor Relations
Antje Witte
T: +32.2.559.94.14
antje.witte@ucb.com

 
About UCB
UCB, Brussels, Belgium (www.ucb.com) is a global biopharmaceutical company focused on the discovery and development of innovative medicines and solutions to transform the lives of people living with severe diseases of the immune system or of the central nervous system. With more than 9000 people in approximately 40 countries, the company generated revenue of € 6.1 billion in 2024. UCB is listed on Euronext Brussels (symbol: UCB). Follow us on Twitter: @UCB_news

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References:

1. Barton M, et al. Phase II study of bepranemab in people with prodromal-mild Alzheimer’s disease: Population subgroup analysis. Presented at: AD/PD; 2025 April 1-5; Vienna, Austria.
2. Barton M, et al. Results from TOGETHER, a double-blind, placebo-controlled Phase II study evaluating efficacy, safety and tolerability of bepranemab in prodromal–mild AD. Presented at: 17th Clinical Trials on Alzheimer's Disease (CTAD); 2024 October 29 - November 1; Madrid, Spain.
3. Downey P, et al. A preclinical evaluation of UCB7853, an anti-alpha-synuclein antibody in clinical development for Parkinson’s disease. Presented at: AD/PD; 2025 April 1-5; Vienna, Austria.
4. Kremer P, et al. Phase I study results: UCB7853 safety, tolerability and pharmacokinetics in healthy participants (single-ascending dose) and people with Parkinson’s disease (multiple-ascending doses). Presented at: AD/PD; 2025 April 1-5; Vienna, Austria.
5. Biagioni M, et al. Designing a patient-informed trial: ATLANTIS Phase II study of the D1 receptor PAM, UCB0022, in advanced Parkinson’s disease. Presented at: AD/PD; 2025 April 1-5; Vienna, Austria.
6. https://www.ucb.com/innovation/clinical-studies/clinical-studies-index/UCB7853. Accessed March 2025.
7. https://www.ucb.com/innovation/clinical-studies/clinical-studies-index/UCB0022. Accessed March 2025.
8. Carson S, et al. Results from ORCHESTRA, a phase II proof-of-concept study assessing the efficacy and safety of minzasolmin in people with early-stage Parkinson’s disease. Presented at: AD/PD; 2025 April 1-5; Vienna, Austria.
9. UCB Corporate Website. https://www.ucb.com/newsroom/press-releases/article/findings-from-minzasolmin-proof-of-concept-orchestra-study-shape-next-steps-in-ucb-parkinson-s-research-program. Accessed March 2025.