Systemic Lupus Erythematosus (SLE)
Systemic Lupus Erythematosus (SLE), also known as lupus, is a serious, life-changing chronic autoimmune disease that occurs when the body’s immune system attacks its own healthy tissues and organs 1,2,3.
Inflammation caused by SLE can affect many different body systems, including the skin, joints, kidneys, blood cells, brain, heart and lungs 1,2. While symptoms are varied, the most distinctive sign of SLE (occurring in most but not all patients) is a facial rash that resembles the wings of a butterfly unfolding across both cheeks 2.
SLE is also characterised by episodes known as flares, when signs and symptoms worsen, and remissions, when the symptoms of the disease improve again or even disappear 1,4.
Fast Facts
SLE is a chronic autoimmune disease 1
The majority of people with SLE are female of childbearing age 1
There is no cure for SLE 3
The cause of SLE is not known 3
The goals of treatment are to suppress the overactive immune system, reduce inflammation, control symptoms, prevent flares and minimize damage to organs 5
SLE is a disease of flares and remissions 1
Who gets lupus?
The majority of people with SLE are women of childbearing age between the ages of 15 and 44 years. Men, children and teenagers can also be affected 1,3. People of all races and ethnic groups can develop SLE 1.
The course of lupus varies by individual and symptoms come (flares) and go (remission). There is no way to predict when a flare will happen, how bad it will be, or how long it will last.
Diagnosis is difficult and time-consuming, as there is no single test that can determine whether a person has or will develop lupus, and the diagnosis is based on a combination of physical symptoms and laboratory results.
Signs & Symptoms
Symptoms may include 4,7
Extreme fatigue
Headaches, confusion, memory loss
Joint pain, stiffness and swelling
Hair loss
Haematologic disorders, such as anaemia
Fever
Shortness of breath
Miscarriage (especially regarding Hughes Syndrome)
Facial or other rashes
Weight loss
Skin lesions that appear or worsen with sun exposure
Chest pain
Dry eyes
Neurologic disorders, such as depression
Oral or nasopharyngeal ulcers
Vasculitis
Pleurisy
Myocarditis
Kidney disease
Approximately 5 million people
throughout the world have a form of SLE 1
Patients and families
Lupus has a major impact on the lives of patients, as well as on their families and their wider communities.
The debilitating fatigue and physical symptoms that come with lupus can significantly affect the social functioning of people with the condition.
For example, a typical middle-aged female patient of child-bearing age could find her family life significantly curtailed because her fatigue keeps her from interacting with her children or because she faces diminished family planning and fertility options. She may miss work and face repeated hospitalisation due to illness. She may limit her social and civic activities due to chronic illness. She may face loss of productivity, either through reduced working hours or enforced permanent unemployment.
The symptoms of lupus make it difficult for people with moderate to severe disease to hold down a job. 8
Patients and families
Lupus has a major impact on the lives of patients, as well as on their families and their wider communities.
The debilitating fatigue and physical symptoms that come with lupus can significantly affect the social functioning of people with the condition.
For example, a typical middle-aged female patient of child-bearing age could find her family life significantly curtailed because her fatigue keeps her from interacting with her children or because she faces diminished family planning and fertility options. She may miss work and face repeated hospitalisation due to illness. She may limit her social and civic activities due to chronic illness. She may face loss of productivity, either through reduced working hours or enforced permanent unemployment.
The symptoms of lupus make it difficult for people with moderate to severe disease to hold down a job. 8
Controlling lupus
Although there are medications to help reduce the signs and symptoms, there is no cure for SLE 2,3,6. The goals of treatment are to improve quality of life by suppressing the overactive immune system, reducing inflammation and gaining control over symptoms, prevent flares, and minimise damage to organs 5.
SLE is treated by a rheumatologist; however, if damage has been caused to a particular organ, other specialists will be consulted 5. As signs and symptoms flare and subside, treatment may need to be altered or doses adjusted 6.