Levetiracetam (Keppra®)
| Disease area studied | Abbreviated title | Phase | Study ID | Registry database | Study results | Plain language summary | Publication (if available) |
|---|---|---|---|---|---|---|---|
| Epilepsy | A Study of Levetiracetam as Monotherapy or Adjunctive Treatment of Partial Seizures in Pediatric Epileptic Subjects Ranging From 1 Month to Less Than 4 Years of Age | Phase 3 |
EP0100
Completed |
NCT03340064 2021-003372-13 |
LINK LINK |
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| Epilepsy | A Placebo-controlled Study of Levetiracetam In Children (1mo to 4yrs of Age) With Partial Onset Seizures. | Phase 3 |
N01009
Completed |
NCT00175890 2004-000199-14 |
LINK
|
Pina-Garza et al. Epilepsia;2009;50(5);1141-1149. | |
| Epilepsy | Follow-up Study of L059 (Levetiracetam) in Epileptic Patients With Partial Onset Seizures by Open Label Method | Phase 3 |
N01020
Completed |
NCT00160615 |
LINK
|
"Yagi, K., J Japan Epilepsy Society;2-10-2012;29;3;441-454 [In Japanese] " | |
| Epilepsy | S.K.A.T.E.: Safety of Keppra as Adjunctive Therapy in Epilepsy | Phase 4 |
N01031
Completed |
NCT00630968 | Steinhoff et al. Epilepsy Res;2007;76(1);6-14. | ||
| Epilepsy | Pharmacovigilance Study of Keppra. SPAIN - SKATE : Safety of Keppra as Adjunctive Therapy in Epilepsy | Phase 4 |
N01033
Completed |
NCT00643500 | Salas-Puig et al. Rev Neurol;2004;16-30;38;1117–1122. [in Spanish] | ||
| Epilepsy | A Phase IV-Pharmacovigilance Study of Keppra Greece - S.K.A.T.E.: Safety of Keppra as Adjunctive Therapy in Epilepsy | Phase 4 |
N01035
Completed |
NCT00631150 | |||
| Epilepsy | Open Label Safety and Efficacy Study of Levetiracetam in Patients With Epilepsy | Phase 4 |
N01036
Completed |
NCT00160654 |
LINK
|
Kwan et al. Epilepsy Behav;2010;18(1-2);100-105. | |
| Epilepsy | Trial to Evaluate the Safety and Efficacy of Keppra After Conversion to Mono-therapy in Subjects With Partial Epilepsy | Phase 4 |
N01037
Completed |
NCT00630357 | |||
| Epilepsy | Pharmacokinetic Study of Levetiracetam in Epileptic Pediatric Subjects Ranging in Age From 1 Month to Less Than 4 Years Old | Phase 2 |
N01052
Completed |
NCT00544050 | Glauser et al. Epilepsia;2007;48(6);1117-1122. | ||
| Epilepsy | Study to Evaluate the Safety and Efficacy of Levetiracetam in Patients Suffering From Idiopathic Generalized Epilepsy With Primary Generalized Tonic-clonic Seizures | Phase 3 |
N01057
Completed |
NCT00160550 | Berkovic et al. Neurology;2007;69(18);1751-1760. | ||
| Epilepsy | Monotherapy With Levetiracetam in Newly Diagnosed Patients Suffering From Epilepsy | Phase 3 |
N01061
Completed |
NCT00150735 | Brodie et al. Neurology;2007;68(6);402-408. | ||
| Epilepsy | Determine Effects of Adjunctive Levetiracetam on Sleep Architecture in Adults With Partial Onset Epilepsy. | Phase 4 |
N01085
Completed |
NCT00245713 | |||
| Anxiety Disorder | Study to Assess the Efficacy and Safety of Levetiracetam for the Treatment of Social Anxiety Disorder (Generalized Type) | Phase 2 |
N01086
Completed |
NCT00612859 | "Stein, M. B. et al., Journal of Clinical Psychiatry;2010;71;5;627-631 " | ||
| Postherpetic Neuralgia | A 16 Week Study Evaluating Levetiracetam in the Treatment of Post Herpetic Neuralgia (PHN) | Phase 2 |
N01087
Completed |
NCT00160511 | |||
| Epilepsy | Study on Safety and Efficacy of Levetiracetam in the Adjunctive Treatment of Female Subjects With C1 Catamenial Epilepsy | Phase 4 |
N01088
Completed |
NCT00630630 | |||
| Epilepsy | Monotherapy With Levetiracetam or Carbamazepine in Patients Suffering From Epilepsy. | Phase 3 |
N01093
Completed |
NCT00150787 | Sethi et al. Neurology;2007;69(9);937-938. | ||
| Epilepsy | Open Label Safety and Efficacy Study of Levetiracetam in Korean Patients With Epilepsy | Phase 3 |
N01099
Completed |
NCT00160628 | Heo et al. Seizure;2007;16(5);402-409. | ||
| Epilepsy | Double-blind, Placebo-controlled Study of Levetiracetam in Adults With POS | Phase 3 |
N01102
Completed |
NCT00152373 | Wu et al. Epilepsia;2009;50(3);398-405. | ||
| Epilepsy | A 19-week Cognition Study of Levetiracetam in Children With Partial Onset Seizures | Phase 2 |
N01103
Completed |
NCT00105040 2014-004396-23 |
LINK
|
Levisohn et al. Epilepsia;2009;50(11);2377-2389. | |
| Parkinson's Disease | Levetiracetam Treatment in Adult Subjects With Parkinson's Disease Experiencing Troublesome Dyskinesias | Phase 2 |
N01105
Completed |
NCT00160576 | "Ferreira, J. Eur J Neurol;2004;11;Suppl 2;331 8th Congress of the European Federation of Neurological Societies (EFNS), September 4-7, 2004;Paris, France " | ||
| Epilepsy | Monotherapy With Levetiracetam in Patients Suffering From Epilepsy. | Phase 3 |
N01127
Completed |
NCT00150813 |
LINK
|
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| Tardive Dyskinesia | Levetiracetam in the Treatment of Neuroleptic-induced Tardive Dyskinesia | Phase 2 |
N01142
Completed |
NCT00175955 2004-001302-27 |
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| Epilepsy | Long-Term, Follow-Up Study Of the Safety And Efficacy Of Levetiracetam In Children With Partial Onset Seizures | Phase 3 |
N01148
Completed |
NCT00152516 2004-000200-40 |
LINK LINK |
Schiemann-Delgado et al.J Child Neurol;2012;27(1);80-89. | |
| Epilepsy | A Double-blind, Placebo-controlled Study of Levetiracetam in Epilepsy Patients With Generalized Tonic-clonic Seizures Except Partial Seizures Evolving to Secondarily Generalized Seizures) | Phase 3 |
N01159
Completed |
NCT01228747 2014-004401-32 |
LINK LINK |
Wu L., et al. Epilepsia Open 2018; 3(4):474–84 | |
| Epilepsy | Safety and Tolerability of Levetiracetam Intravenous 15 Minute Infusion in Subjects Suffering From Partial Onset Seizures | Phase 2 |
N01166
Completed |
NCT00610454 | Baulac et al. Epilepsia;2007;48(3);589-592. | ||
| Epilepsy | Levetiracetam Versus Standard Antiepileptic Drugs (Carbamazepine and Valproate) Used as Monotherapy in Patients With Newly Diagnosed Epilepsy | Phase 3 |
N01175
Completed |
NCT00175903 2004-001339-41 |
LINK
|
"Trinka et al. J Neurol Neurosurg Psychiatry;2013;84(10);1138-1147 Pohlmann-Eden, B., et al. BMC Neurol;2016;16;1;149." | |
| Epilepsy | A Double-blind Confirmatory Trial of L059 (Levetiracetam) in Epilepsy Patients With Partial Onset Seizures | Phase 3 |
N01221
Completed |
NCT00280696 2014-004333-57 |
LINK
|
Inoue, Y. et al., Psychiatry Clin Neurosci;2015;69;10;640-648 | |
| Epilepsy | A Long Term Follow up Administration Study of L059 (Levetiracetam) in Epilepsy Patients With Partial Onset Seizures | Phase 3 |
N01222
Completed |
NCT00367432 2014-004334-26 |
LINK LINK |
"Yagi, K., Japan J Clin Psychopharm;2016;19;1027-1040 [In Japanese] " | |
| Epilepsy | An Open Label Study of Levetiracetam in Japanese Pediatric Patients With Partial Seizures | Phase 3 |
N01223
Completed |
NCT01063764 2014-004335-39 |
LINK LINK |
Nakamura et al. Brain Nerve;2013;65(9);1083-1092. [in Japanese] | |
| Epilepsy | A Study to Look at the Efficacy and Safety of Keppra® Extended Release Formulation - XR | Phase 3 |
N01235
Completed |
NCT00368069 2006-000987-10 |
LINK LINK |
Peltola et al. Epilepsia;2009;50(3);406-414. | |
| Epilepsy | Follow up Trial for Keppra (Levetiracetam) as Monotherapy in Patients With Newly Diagnosed Epilepsy Coming From N01175 (NCT00175903). | Phase 3 |
N01237
Completed |
NCT00291655 2006-000173-29 |
LINK LINK |
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| Epilepsy | Cross Sectional Study to Evaluate the Acceptability of Oral Solution of Levetiracetam | Phase 4 |
N01242
Completed |
NCT00319605 | Matías-Guíu et al. Methods Find Exp Clin Pharmacol;2010;32(7);507-516. | ||
| Epilepsy | Open-label Study of Levetiracetam Intravenous Infusion in Children (4-16 Years Old) With Epilepsy | Phase 2 |
N01274
Completed |
NCT00535392 2006-005722-23 |
LINK LINK |
"Weinstock et al. J Child Neurol;2013;28(11);1423-1429. " | |
| Epilepsy | Open-label Study of Levetiracetam Intravenous Infusion in Children (1 Month-4 Years Old) With Epilepsy | Phase 2 |
N01275
Completed |
NCT00505934 2007-003517-13 |
LINK LINK |
Weinstock et al. J Child Neurol;2013;28(11);1423-1429. | |
| Epilepsy | Conversion to Monotherapy Study With Keppra XR for Partial Seizures | Phase 3 |
N01280
Completed |
NCT00419094 2007-000897-21 |
LINK LINK |
Chung,S. et al. Epilepsy Res;2012;101(1-2);92-102. | |
| Epilepsy | Long Term Follow-up Study With Keppra XR (Levetiracetam XR) for Partial Seizures | Phase 3 |
N01281
Completed |
NCT00419393 2007-000899-17 |
LINK LINK |
Chung, S., et al. Epilepsy Res;2016;120;7-12 | |
| Epilepsy | Study Evaluating the Pharmacokinetics of Keppra Extended Release (XR) in Children and Adults With Epilepsy | Phase 2 |
N01340
Completed |
NCT00961441 2014-004376-39 |
LINK LINK |
"Naritoku et al. Epilepsy Curr;2010;11;1 Suppl. 1. 64th Annual Meeting of the American Epilepsy Society (AES), December 3-7, 2010;San Antonio, USA." | |
| Epilepsy | Levetiracetam Versus Topiramate as Adjunctive Therapy to Evaluate Efficacy and Safety in Subjects With Refractory Partial Onset Seizures | Phase 4 |
N01353
Completed |
NCT01229735 2014-004402-15 |
LINK LINK |
Lee S.K., et al. Epilepsy Behav 2019; 97:67–74 | |
| Epilepsy | An Open Label Study of L059 (Levetiracetam) in Japanese Epilepsy Subjects With Generalized Tonic-clonic Seizures | Phase 3 |
N01361
Completed |
NCT01398956 2016-002879-96 |
LINK LINK |
Yagi K et al. Japan J Clin Psychopharm. 2018;21:1609-1622 [In Japanese] | |
| Epilepsy | A Study of Levetiracetam in Japanese Pediatric Patients With Generalized Tonic-clonic Seizures | Phase 3 |
N01363
Completed |
NCT01292837 2014-004382-25 |
LINK LINK |
"Ohtsuka, Y. et al Japan J Clin Psychopharm;2016;19;3;347-359 [in Japanese]" | |
| Epilepsy | Open-label, Randomized, Active-controlled Study of LEV Used as Monotherapy in Patients With Partial-Onset Seizures | Phase 3 |
N01364
Completed |
NCT01954121 2015-004586-84 |
LINK LINK |
Liao W., et al. J Child Neurol 2020; 33(5) [In Chinese] | |
| Epilepsy | Levetiracetam Versus Oxcarbazepine as Monotherapy to Evaluate Efficacy and Safety in Subject With Partial Epilepsy | Phase 4 |
N01367
Completed |
NCT01498822 2014-002713-32 |
LINK LINK |
"Kim, J. H. et al Epilepsia;2017;58;4;e70-e74 " | |
| not applicable (pharmacokinetics study) | Pharmacokinetic (PK) Study in Japanese Non-epileptic Renal Impaired Patients | Phase 4 |
N01373
Completed |
NCT01491113 |
LINK
|
Yamamoto, J. et al., Clin Drug Investig;2014;34;11;819-828 | |
| Epilepsy | An Open Label Study of Levetiracetam Monotherapy in Newly Diagnosed Epilepsy With Partial Onset Seizure | Phase 3 |
N01375
Completed |
NCT01506882 2014-004377-16 |
LINK LINK |
Kaneko, S. et al. ,J Japan Epilepsy Society;2015;32;3;519-532 [ In Japanese] | |
| Epilepsy | An Open Label Study of L059 Intravenous (IV) in Japanese Epilepsy Subjects With Partial Onset Seizures | Phase 2 |
N01378
Completed |
NCT01407523 |
LINK
|
Inoue, Y. et al., Jpn J Clin Psychopharmacol;2014;17;413-422 [In Japanese] | |
| Epilepsy | A study to learn if levetiracetam reduced seizures in participants with epilepsy | Phase 3 |
N051
Completed |
Boon P., et al. Epilepsy Res 2002; 48(1-2):77–89 | |||
| Epilepsy | A study to learn if levetiracetam works in participants with epilepsy who are taking their usual anti-seizure medicines | Phase 3 |
N132
Completed |
Cereghino J.J. et al. Neurology 2000; 55(2):236–42 | |||
| Epilepsy | A study to learn if levetiracetam reduced seizures in participants with epilepsy | Phase 3 |
N138
Completed |
Ben-Menachem E., et al. Epilepsia 2000; 41(10):1276–83 | |||
| Epilepsy | A Study Of The Safety And Efficacy Of Levetiracetam (Keppra®) (Ucb L059) In Children With Epilepsy | Phase 3 |
N157
Completed |
NCT00150709 |
LINK
|
" Glauser et al. Epilepsia;2005;46;Suppl 6;102. 26th International Epilepsy Congress (IEC), August 28-September 1, 2005;Paris, France. " | |
| Epilepsy | Efficacy and Tolerability of Levetiracetam Add-On Treatment in Refractory Pediatric Patients With Partial Onset Seizures | Phase 3 |
N159
Completed |
NCT00615615 | Glauser et al. Neurology;2006;66(11);1654-1660. | ||
| Epilepsy | A Safety and Efficacy Follow-up Study With Levetiracetam in Children (4-17 Years Old) Suffering From Absence Seizures | Phase 2 |
N164
Completed |
NCT00545012 | |||
| Epilepsy | Bridging Study of L059 (Levetiracetam) in Patients With Epilepsy by Double Blind Method | Phase 2 |
N165
Completed |
NCT00600509 | Yagi, K. et al., J Japan Epilepsy Society;7-5-2010;28;1;3-16 [In Japanese] | ||
| Epilepsy | Levetiracetam as add-on Treatment of Myoclonic Jerks in Adolescents + Adults | Phase 3 |
N166
Completed |
NCT00150774 | "Noachtar et al. Neurology;2-19-2008;70;8;607-616 Rosenfeld et al. Epilepsy Res;2009;85(1);72-80. " | ||
| Epilepsy | Long Term Follow up Treatment With Levetiracetam in Subjects of 4 Years and Older With Generalized Epilepsy | Phase 3 |
N167
Completed |
NCT00150748 2004-001997-13 |
LINK |
Delanty et al. Epilepsia;2012;53(1);111-119. |